Amar L, Baudin E, Burnichon N, et al. Some authors reported that tumors with SDHB mutations are associated with shorter survival (24). Students who require financial aid can apply for scholarships in order to study higher education at a lower cost. No patients died during the follow up period with a mean follow up period of 16 months Learn more about our products. Widespread of this called score with complete clinical data will help to validate these findings and to add other prognostic factors of value that could be a part of this scaled score such as immunohistochemical findings. Medicine School of Tunis(arabic: كلية الطب بتونس) (french: faculté de médecine de Tunis) (FMT) is one of the four medical schools in Tunisia. VHL Germline Mutations in Pheochromocytoma. Thompson LDR, Young WF, Kawashima A, Komminoth P, Tischler AS. Privacy Policy -Terms & Conditions - This page contains contact information, location maps, and email addresses. Pathology The succinate dehydrogenase Nature genetics 2010;42:229-35. Tumor cell monotony was identified in 3 cases. Malignant Circulationsapparat und Retinitis. Contact Us. The first one presented a malignant recurrence discovered after 11 years of follow up. Others, suppose that tumors with PASS score >= 4 should be followed closely for recurrence and those with PASS score >= 6 are potentially malignant (23). Tumori 1996;82:480-4. Two patients presented a malignant pheochromocytoma and the other patients presented benign tumors. The tumors involved the right adrenal gland (n= 5 tumors) more frequently than the left adrenal gland (n=3). Help: Soccer results service at Soccer 24 offers an ultimate soccer resource covering major leagues as well as lower divisions for most of popular soccer countries. Organ of the Tunisian society of Medical Sciences and the National Council of the Medical Association of Tunisia ISSN : 0041-4131 IeSSN : 2724-7031 Adresse : Rue Malaga, 2092 El Manar 1 Tél. The mean age of the patients at presentation was 47, 44 years. The recognition of a germline mutation is an important part of the overall management of a patient since it directs investigation for other tumors such as hemangioblastoma and renal cell carcinoma in VHL syndrome. Succinate Dehydrogenase B A summary of the clinical information on the patients is provided in table 1. Receiver operating characteristics (ROC) curve analysis was performed to evaluate the diagnostic performance of PASS. Hartmut PH, Neurmann M, Vortmeyer A, et al. They are slender, with thin wisps of cytoplasm encompassing the chief cells (16). The few number of the cases reported is due to the rarity of the complete adequate follow up information and hematoxylin and eosin-stained slides to make a definitive diagnosis. A pathologist blinded to clinical outcome, reviewed the histopathologic characteristics of all cases using the PASS system. Performance Liquid Chromatography Detection of SDHB, SDHD, and Important: Jump-Start Your Practice Order the Official SAT Subject Test Study Guide in Biology and get two full-length practice tests, detailed answer explanations, tips, and more. Evidence of MEN-2 in Clinical experience with malignant pheochromocytomas. Hertwig O, ed. Scott HWJ, Reynolds V, Green N, et al. The tumors were soft, gray-tan to brow-red with extensive cystic degeneration in one case.Malignant: both patients presented with unilateral disease. A well-formed tumor capsule was present in both cases. Tumours of endocrine organs. Table 4 shows the different PASS scores. The table 2 shows the different results in benign and malignant pheochromocytoma. Urology 2006;68:282-6. Only 4 patients had I-metaiodobenzylguanine (MIBG) scintigraphy. Web Design by Grafdom, Private Higher School of Aeronautics and Technologies, Private International Polytechnic School of Sfax, Université Privée d'Enseignement Supérieur El Amel, UAE ICT Fund announces 100 new scholarships to enhance the sector, Dubai’s Most Affordable Areas for Education & Rent (2019), Khalifa University hosts strategic meeting on UAE-Japan Research and Development, Vocational training never been more important, says Essa Bin Hadher, Top 10 Universities in Canada on Facebook (Infographic), Using technology in the business of education, 8 Top Career Skills to Prepare for Industry 4.0, 6 Things to Consider when Searching for a Master’s Degree Program, Education Policy Reform in the UAE: Building Teacher Capacity. Heitz PU, Eng C.World Health Organization Classification of tumours: Comparison of adrenal and extra adrenal pheochromocytomas. The first one presented MEN2 syndrome and a malignant recurrence with abdominal lymph nodes and liver metastases after 5 years of follow up. The main cell is the chief cell or pheochromocyte which can be detected on routine hematoxylin and eosinestained slides. In MEN2 and VHL-related pheochromocytomas, about 25% are reported as malignant on up to 25 year follow up (6). A score >4 has a sensitivity of 32% and a specificity of 99%. With a population of 10,982,754, Tunisia is the northernmost country in Africa which covers 165,000 square kilometres. Focal vascular invasion was noted in 3 cases. Tunis; Campus Universitaire, Tunis El-Manar, 2092 Tunis, Tunisia. Benign Table 5: Coordinates of the ROC curve The International Society on Thrombosis and Haemostasis (ISTH) diagnostic scoring system enables early diagnosis of DIC. Laboratory values were available in all patients. Both patients were managed by surgery followed by chemotherapy and no patients died after a follow up period of 3 years and 1 year. In our study, one patient presenting syndromic presentation had unilateral tumor, in the other hand, another one presented bilateral tumours without other special findings, but an additional genetic study seems to be compulsory in order to rule it out. Neumann HP, Bausch B, Mc Whinney SR, et al. Many authors claim that PASS score doesn’t allow for clear-cut histological diagnosis of benign and malignant tumors putting emphasis, in some cases,on the significant inter observer and intra observer variation in assignment of PASS with variable interpretation of pathology (23). No patient was asymptomatic. It is an autosomal dominant cancer syndrome with germline mutations in the RET protooncogene. Mitotic figures were inconspicuous or absent in all cases. Cancer 1988;62:2451-60. Back. Clinical experience with Pathol 1985;16:580-9. The tumors were soft, gray-tan with calcification. CONCLUSION Opocher G, Schiavi F, Cicala MV, et al. Benign Poll H. Die vergleichende Entwicklung der nebennierensysteme. Nevertheless, in our study one patient with MEN2 presented a malignant recurrence after a follow up period of 11 years. A d renal The 2 patients presented malignant recurrences. Ist Fresenius Medical Care der richtige Arbeitgeber für Dich? This confers a PPV and NPV of 88%. genetic testing in a large series of patients with paragangliomas. Education is given a high priority and accounts for 6% of GNP. making. in multiple endocrine neoplasia type 2b syndrome: case report and Although special studies weren’t included in the PASS, the S-100 protein reaction was of interest in the diagnosis of MPA. The ROC curve is represented in figure 1. Search the world's information, including webpages, images, videos and more. In the three cases of recurrent tumors, the PASS score was constant in 1case of malignant pheochromocytoma. It is estimated that hereditary tumors are observed in 30 to 40% of cases (15), in the other side, sporadic tumor have a 10 to 15% risk of developing a In general, varied-sized suprarenal masses were identified, often displacing the kidneys. It increased in one case of malignant pheochromocytoma and decreased in one case of benign pheochromocytoma. This fact points out the absence of relevant importance of these markers to make the difference between benign and malignant pheochromocytomas. A PASS score was performed in all cases identifying presumably benign tumors with a PASS score less than 4 and malignant ones with a PASS score equal or superior to 4. Level 3, 247 Adelaide Street, Brisbane QLD 4000, GPO Box 2453, Brisbane QLD 4000. Informiere dich hier: www.bewusster-ernaehren.de Noch ein Grund zur Freude: Wir kaufen Kakao, der zu 100% UTZ-zertifiziert ist, um den nachhaltigen Kakaoanbau zu verbessern. Tumor cell spindling wasn’t noted. Tunisia Document type Regulation Date 2011 Source FAO, FAOLEX Subject Livestock Keyword Animal health Quarantine Pests/diseases Hygiene/sanitary procedures Geographical area Africa, Northern Africa Abstract. Samaan NA, Hickey RC, Shutts PE. Nebennierentumor und gleichzeitiger Nephritis mit Veranderungen am Laboratoire LAB2M. Unlike other medical imaging core labs, Bioclinica has both depth and breadth of experience in GI imaging. The majority of tumors showed areas of degenerative changes, including cyst formation, hemorrhage and fibrosis. Malignant recurrence was defined as the appearance of metastasis after complete tumor eradication. pheochromocytoma of the adrenal gland scaled score for predicting the original description of classic pheochromocytoma. J Clin The closing plenary of our conference presents the important issue of Physiopathological mechanisms of thrombotic events linked to COVID-19 . : +216 71 883 775 Fax : +216 71 883 588 E-mail : stsm@planet.tn. Ces années sont composées de 2 ans en PCEM ou premier cycle des études médicales, 3 ans en deuxième cycle ou DCEM et les deux dernières années en internat obligatoires. Ann Chir 2005; 130:273-76. This fact may be secondary to the few number of cases and the low surface area under the ROC curve. The mean age at presentation was 26 years. One hundred cases of pheochromocytoma (107 tumors) 3-2 Microscopic findings It is considered to be the only full democracy in the Arab World. A summary of the clinical information on the patients in this series is provided in table 1. In this study, the mean age was 43 years. patients. A decisional diagram has been proposed in order to point out the most reliable gene to analyze in every case (28). Read more. This confers a PPV of 33% but a NPV of 99%. Moreover, in pheochromocytoma with diffuse spindle cell formation, the diagnoses of malignant peripheral nerve sheath tumors, which express also S-100 protein must be ruled out. La tunisie Medicale - 2020 ; Vol 98 ( n°012 ) COVID DOSSIER : REFLEXION. Hematoxylin and eosin-stained slides from all patients were reviewed for morphologic assessment of malignant and benign pheochromocytoma. Mirallié E, Cariou B, Kraeber-Bodéré F. bilateral pheochromocytoma. In malignant tumors, the PASS score was >=4 in both cases. Recorded Webinar. 1886;103:244-63. 3. DISCUSSION Diagnosis, localization, and Below is a comprehensive list of all universities in Tunisia (Agareb, Ain Djeloula, Ain Draham, Ajim (Djerba), Akouda, Alaa, Amiret El Fhoul, Amiret El Hojjaj, Amiret Touazra, Aousja, Ariana, Azmour, Bargou, Beja, Bekalta, Bembla-Mnara, Ben Arous, Ben Gardane, Benen Bodher, Beni Hassen, Beni Khalled, Beni Khedache, Beni Khiar, Beni M'Tir, Bir Ali Ben Khelifa, Bir El Hafey, Bir Lahmar, Bir Mcherga, Bizerte, Borj El Amri, Bou Arada, Bou Argoub, Bou Hajla, Bou Merdes, Bou Mhel el-Bassatine, Bou Salem, Bouficha, Bouhjar, Carthage, Cebalet, Chebba, Chebika, Chenini Nahal, Cherahil, Chihia, Chorbane, Dahmani, Dar Allouch, Dar Chaabane, Degache, Dehiba, Den Den, Djebel Oust, Djedeida, Djemna, Douar Hicher, Douz, Echrarda, El Ain, El Alia, El, Aroussa, El Battan, El Bradaa, El Djem, El Fahs, El Golaa, El Guettar, El Hamma, El Haouaria, El Hencha, El Kef, El Krib, El Ksar, El Ksour, El Maagoula, El Maamoura, El Masdour, El Mida, El Mourouj, Enfidha, Essouassi, Ettadhamen-Mnihla, Ezzahra, Ezzouhour, Fernana, Foussana, Gaafour, Gabes, Gafsa, Ghannouch, Ghar al Milh, Ghardimaou, Ghenada, Ghomrassen, Ghraiba, Tunisia, Goubellat, Gremda, Grombalia, Haffouz, Haidra, Hajeb El Ayoun, Hamet Jerid, Hammam Chott, Hammam Ghezeze, Hammam Lif, Hammam Sousse, Hammamet, Hebira, Hergla, Houmt El Souk (Djerba), Jebiniana, Jedelienne, Jemmal, Jendouba, Jerissa, Jilma, Kairouan, Kalaa Kebira, Kalaa Seghira, Kalaat el-Andalous, Kalaat es Senam, Kalaat Khasba, Kasserine, Kebili, Kelibia, Kerkennah, Kerker, Kesra, Khalidia, Khniss, Kondar, Korba, Korbous, Ksar Hellal, Ksibet El Mediouni, Ksibet Thrayet, Ksour Essef, La Goulette, La Marsa, La Soukra, Le Bardo, Le Kram, Lemta, M'saken, Magel Bel, Abbes, Mahares, Mahdia, Majaz al Bab, Maktar, Manouba, Mareth, Mateur, Matmata, Mdhila, Medenine, Megrine, Meknassy, Mellouleche, Menzel Abderrahmane, Menzel Bourguiba, Menzel Bouzaiane, Menzel Bouzelfa, Menzel Chaker, Menzel Ennour, Menzel Farsi, Menzel Hayet, Menzel Horr, Menzel Jemil, Menzel Kamel, Menzel Mehiri, Menzel Salem, Menzel Temime, Messaadine, Metlaoui, Metline, Metouia, Mezzouna, Midoun (Djerba), Mohamedia-Fouchana, Moknine, Monastir, Mornag, Mornaguia, Moulares, Nabeul, Nadhour, Nafta, Nasrallah, Nebeur, Nefza, Nouvelle Matmata, Oudhref, Oued Ellil, Oued Melliz, Ouerdanin, Oueslatia, Ouled Chamekh, Ouled Haffouz, Rades, Raf Raf, Raoued, Ras Jebel, Redeyef, Regueb, Rejiche, Remada, Rouhia, Sahline Mootmar, Sakiet Eddaïer, Sakiet Ezzit, Sakiet Sidi Youssef, Sayada, Sbeitla, Sbiba, Sbikha, Sejnane, Sened, Sers, Sfax, Sidi Ali Ben Aoun, Sidi Alouane, Sidi Ameur, Sidi Bennour, Sidi Bou Ali, Sidi Bou Rouis, Sidi, Bou Said, Sidi Bouzid, Sidi El Hani, Sidi Hassine, Sidi Thabet, Siliana, Skhira, Soliman, Somaa, Souk Lahad, Sousse, Tabarka, Tajerouine, Takelsa, Tamerza, Tataouine, Tazerka, Teboulba, Tebourba, Teboursouk, Testour, Thala, Thelepte, Thyna, Tinja, Touiref, Touza, Tozeur, Tunis, Zaghouan, Zahret Medien, Zaouiet Djedidi, Zaouiet Kontoch, Zaouiet Sousse, Zarat, Zarzis, Zeramdine, Zriba).